Effects of Prolonged Serum Calcium Suppression during Extracorporeal Cardiopulmonary Resuscitation in Pigs

Controlled reperfusion by monitoring the blood pressure, flow, and specific parameters during extracorporeal after cardiac arrest has potential to limit ischemia–reperfusion injury. The intracellular calcium overload as part of injury provides possibility for be counteracted early suppression serum with aim improving survival neurological outcome. We investigated effects prolonged via sodium citrate resuscitation using CARL protocol (CARL—controlled automated whole body) compared a single-dose approach in porcine model arrest. A control group (N = 10) was resuscitated 20 min arrest, initially lowering intravascular help single dose priming solution. Animals intervention 13) received additional first 15 reperfusion. In group, 9/10 (90.0%) animals survived until day 7 7/13 (53.8%) (p 0.09). favorable outcome on observed all surviving species-specific deficit score. coronary perfusion pressure significantly lower tendency towards more arrhythmias group. conclusion, reduction levels over tended unfavorable regarding hemodynamic variables this animal model.